Short chain aldehydes appear to bind to the receptor but not

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n95 face mask The mouse I7 odorant receptor differs from the rat I7 receptor by a single valine to isoleucine substitution; this gives its strongest response with heptanal. The rat I7 odorant receptor (OR 17) gives a strong response to straight chain C7 C10 aldehydes, most strongly to octanal, but not to aldehydes with less than 7 or more than 10 carbons. Short chain aldehydes appear to bind to the receptor but not to activate it; aldehydes above C11 are too big to fit the binding pocket. n95 face mask

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